Week 0 (Aug 26 – 27)
District 6 – August 26, 2022
| Altoona (Dist 6 AAAAAA 3-0-0) 19 Hollidaysburg (Dist 6 AAAAA 0-3-0) 9 |
| Claysburg-Kimmel (Dist 6 A 1-2-0) 19 Everett (Dist 5 AA 0-3-0) 14 |
| Homer Center (Dist 6 A 2-1-0) 28 United (Dist 6 AA 0-3-0) 6 |
| Juniata Valley (Dist 6 A 1-2-0) 23 Glendale (Dist 6 A 0-3-0) 12 |
| Mifflin County (Dist 6 AAAAAA 2-1-0) 14 Central Mountain (Dist 6 AAAAA 0-3-0) 7 |
| Mount Union (Dist 6 AA 2-1-0) 7 Huntingdon (Dist 6 AA 1-2-0) 0 |
| Northern Cambria (Dist 6 A 3-0-0) 35 Cambria Heights (Dist 6 A 2-1-0) 28 |
| Penns Manor (Dist 6 A 3-0-0) 32 Purchase Line (Dist 6 A 1-2-0) 0 |
| Penns Valley (Dist 6 AA 3-0-0) 41 Line Mountain (Dist 4 AA 0-3-0) 13 |
| Philipsburg-Osceola (Dist 6 AA 1-2-0) 49 West Branch (Dist 6 A 1-2-0) 20 |
| Portage (Dist 6 A 2-1-0) 40 River Valley (Dist 6 AA 0-3-0) 6 |
| State College (Dist 6 AAAAAA 3-0-0) 42 Williamsport (Dist 4 AAAAAA 1-2-0) 14 |
| Tyrone (Dist 6 AAA 3-0-0) 27 Bellwood-Antis (Dist 6 AA 2-1-0) 12 |
| Westmont Hilltop (Dist 6 AA 1-2-0) 21 Central Cambria (Dist 6 AA 1-2-0) 19 |
| West Shamokin (Dist 6 AA 2-1-0) 40 Marion Center (Dist 6 A 0-3-0) 7 |
District 4 – August 26, 2022
| Bucktail (Dist 4 A 1-1-0) 42 Sheffield (Dist 9 A 0-2-0) 12 |
| Canton (Dist 4 A 3-0-0) 31 Union Area (Dist 7 A 2-1-0) 18 |
| Central Columbia (Dist 4 AA 1-2-0) 28 Shikellamy (Dist 4 AAAA 1-2-0) 27 |
| Danville (Dist 4 AAA 3-0-0) 58 Bloomsburg (Dist 4 AA 2-1-0) 0 |
| Hughesville (Dist 4 AA 1-2-0) 42 Montgomery (Dist 4 A 1-2-0) 0 |
| Jersey Shore (Dist 4 AAAA 3-0-0) 55 Pottsville (Dist 11 AAAA 1-2-0) 12 |
| Loyalsock (Dist 4 AAA 3-0-0) 34 Berks Catholic (Dist 3 AAAA 0-3-0) 21 |
| Mifflinburg (Dist 4 AAAA 3-0-0) 54 Midd-West (Dist 4 AAA 1-2-0) 0 |
| Milton (Dist 4 AAA 3-0-0) 28 South Williamsport (Dist 4 AA 2-1-0) 0 |
| Montoursville (Dist 4 AAA 2-1-0) 21 Wellsboro (Dist 4 AA 0-3-0) 14 |
| Mount Carmel (Dist 4 AA 3-0-0) 25 North Schuylkill (Dist 11 AAA 2-1-0) 17 |
| Muncy (Dist 4 A 2-0-0) 56 Warrior Run (Dist 4 AA 0-3-0) 6 |
| Selinsgrove (Dist 4 AAAA 2-1-0) 32 Bellefonte (Dist 6 AAAA 0-3-0) 0 |
| Southern Columbia (Dist 4 AA 2-1-0) 42 Berwick (Dist 2 AAAA 1-2-0) 27 |
| Towanda (Dist 4 AA 1-1-0) 34 North Penn-Mansfield (Dist 4 AAA 0-3-0) 14 |
| Troy (Dist 4 AA 3-0-0) 20 Bald Eagle Area (Dist 6 AA 1-2-0) 9 |
District 5 – August 26, 2022
| Bedford (Dist 5 AAA 3-0-0) 44 Bishop McCort (Dist 6 A 1-2-0) 0 |
| Chestnut Ridge (Dist 5 AA 3-0-0) 30 Somerset (Dist 5 AAA 0-3-0) 7 |
| Northern Bedford (Dist 5 A 3-0-0) 40 Southern Huntingdon (Dist 6 AA 2-1-0) 33 |
| Tussey Mountain (Dist 5 A 1-2-0) 28 Moshannon Valley (Dist 6 A 1-2-0) 14 |
District 8 & 9 – August 26, 2022
| Carrick (Dist 8 AAAA 1-2-0) 14 Carlynton (Dist 7 AA 0-3-0) 0 |
| Brockway (Dist 9 AA 2-1-0) 28 Kane (Dist 9 AA 0-3-0) 25 |
| Central Clarion (Dist 9 AA 3-0-0) 42 Brookville (Dist 9 AA 0-3-0) 7 |
| Curwensville (Dist 9 A 2-1-0) 34 Meyersdale (Dist 5 A 0-2-0) 18 |
| DuBois (Dist 9 AAAA 2-1-0) 28 Karns City (Dist 9 AA 1-2-0) 7 |
| Keystone (Dist 9 A 3-0-0) 33 Coudersport (Dist 9 A 1-2-0) 16 |
| Port Allegany (Dist 9 A 2-1-0) 30 Ridgway (Dist 9 AA 0-3-0) 6 |
| Punxsutawney (Dist 9 AAA 2-1-0) 56 Bradford (Dist 9 AAAA 0-3-0) 0 |
| Redbank Valley (Dist 9 A 3-0-0) 53 Smethport (Dist 9 A 1-2-0) 8 |
| Saint Marys (Dist 9 AAA 3-0-0) 47 Moniteau (Dist 9 AA 1-2-0) 14 |
| Union_AC Valley (Dist 9 A 1-2-0) 27 Cameron County (Dist 9 A 0-3-0) 14 |
District 6 – August 27 2022
| Central (Martinsburg) (Dist 6 AAA 1-2-0) 21 Bishop Guilfoyle (Dist 6 AA 2-1-0) 20 |
| Juniata (Dist 6 AAAA 1-2-0) 20 Clearfield (Dist 9 AAA 2-1-0) 7 |
| Penn Cambria (Dist 6 AAA 3-0-0) 42 Johnstown (Dist 6 AAAA 0-3-0) 6 |
| Richland (Dist 6 AA 3-0-0) 26 Forest Hills (Dist 6 AA 0-3-0) 23 |
District 4 – August 27 2022
| Columbia Montour VT (Dist 4 AAAA 1-2-0) 40 Shenandoah Valley (Dist 11 AA 0-3-0) 14 |
| Shamokin (Dist 4 AAAA 1-2-0) 13 Lewisburg (Dist 4 AAAA 0-3-0) 9 |
District 5- August 27 2022
| Berlin Brothersvalley (Dist 5 AA 3-0-0) 42 Conemaugh Valley (Dist 6 A 0-3-0) 0 |
| Conemaugh Township (Dist 5 A 3-0-0) 49 North Star (Dist 5 AA 1-2-0) 14 |
| Windber (Dist 5 AA 3-0-0) 57 Fairfield (Dist 3 A 0-2-0) 0 |
District 8 & 9 – August 27, 2022
| Perry (Dist 8 AA 1-2-0) 38 Seton LaSalle (Dist 7 AA 0-3-0) 7 |
| Westinghouse (Dist 8 AA 3-0-0) 40 Clairton (Dist 7 A 0-2-0) 8 |
| Elk County Catholic (Dist 9 A 3-0-0) 35 Otto-Eldred (Dist 9 A 2-1-0) 30 |