September 2-3, 2022
District 6 – September 2, 2022
| Altoona (Dist 6 AAAAAA 3-0-0) 35 Allderdice (Dist 8 AAAAAA 0-3-0) 14 |
| Bellwood-Antis (Dist 6 AA 2-1-0) 27 Glendale (Dist 6 A 0-3-0) 0 |
| Bishop McCort (Dist 6 A 1-2-0) 50 Somerset (Dist 5 AAA 0-3-0) 7 |
| Cambria Heights (Dist 6 A 2-1-0) 13 Portage (Dist 6 A 2-1-0) 6 |
| Homer Center (Dist 6 A 2-1-0) 34 River Valley (Dist 6 AA 0-3-0) 20 |
| Huntingdon (Dist 6 AA 1-2-0) 14 Philipsburg-Osceola (Dist 6 AA 1-2-0) 10 |
| Mifflin County (Dist 6 AAAAAA 2-1-0) 35 Shikellamy (Dist 4 AAAA 1-2-0) 13 |
| Northern Cambria (Dist 6 A 3-0-0) 30 Marion Center (Dist 6 A 0-3-0) 0 |
| Penn Cambria (Dist 6 AAA 3-0-0) 42 Central Cambria (Dist 6 AA 1-2-0) 21 |
| Penns Manor (Dist 6 A 3-0-0) 34 United (Dist 6 AA 0-3-0) 0 |
| Penns Valley (Dist 6 AA 3-0-0) 34 Bellefonte (Dist 6 AAAA 0-3-0) 20 |
| Purchase Line (Dist 6 A 1-2-0) 28 West Shamokin (Dist 6 AA 2-1-0) 7 |
| Richland (Dist 6 AA 3-0-0) 35 Central (Martinsburg) (Dist 6 AAA 1-2-0) 28 |
| Southern Huntingdon (Dist 6 AA 2-1-0) 48 Claysburg-Kimmel (Dist 6 A 1-2-0) 13 |
| State College (Dist 6 AAAAAA 3-0-0) 32 Downingtown East (Dist 1 AAAAAA 2-1-0) 31 |
| Tyrone (Dist 6 AAA 3-0-0) 30 Brookville (Dist 9 AA 0-3-0) 0 |
| West Branch (Dist 6 A 1-2-0) 48 Everett (Dist 5 AA 0-3-0) 28 |
District 4 – September 2, 2022
| Athens (Dist 4 AAA 2-1-0) 48 Cowanesque Valley (Dist 4 AAA 0-3-0) 0 |
| Bloomsburg (Dist 4 AA 2-1-0) 42 Central Mountain (Dist 6 AAAAA 0-3-0) 21 |
| Danville (Dist 4 AAA 3-0-0) 52 Line Mountain (Dist 4 AA 0-3-0) 0 |
| Jersey Shore (Dist 4 AAAA 3-0-0) 70 Lewisburg (Dist 4 AAAA 0-3-0) 6 |
| Loyalsock (Dist 4 AAA 3-0-0) 27 Hughesville (Dist 4 AA 1-2-0) 0 |
| Midd-West (Dist 4 AAA 1-2-0) 48 Halifax (Dist 3 A 1-2-0) 14 |
| Mifflinburg (Dist 4 AAAA 3-0-0) 35 Central Columbia (Dist 4 AA 1-2-0) 0 |
| Milton (Dist 4 AAA 3-0-0) 21 Towanda (Dist 4 AA 1-1-0) 7 |
| Mount Carmel (Dist 4 AA 3-0-0) 42 Dunmore (Dist 2 AA 2-1-0) 14 |
| Muncy (Dist 4 A 2-0-0) 30 Wellsboro (Dist 4 AA 0-3-0) 22 |
| Selinsgrove (Dist 4 AAAA 2-1-0) 17 Juniata (Dist 6 AAAA 1-2-0) 14 |
| Southern Columbia (Dist 4 AA 2-1-0) 43 Shamokin (Dist 4 AAAA 1-2-0) 0 |
| South Williamsport (Dist 4 AA 2-1-0) 59 Montgomery (Dist 4 A 1-2-0) 14 |
| Troy (Dist 4 AA 3-0-0) 28 Montoursville (Dist 4 AAA 2-1-0) 7 |
| Williamsport (Dist 4 AAAAAA 1-2-0) 29 Pittston Area (Dist 2 AAAA 1-2-0) 12 |
| Wyalusing (Dist 4 AA 1-2-0) 14 Spencer-Van Etten/Candor (NY) (Dist 99 AAA 0-1-0) 0 |
District 5 – September 2, 2022
| Bedford (Dist 5 AAA 3-0-0) 18 Forest Hills (Dist 6 AA 0-3-0) 7 |
| Berlin Brothersvalley (Dist 5 AA 3-0-0) 42 Moshannon Valley (Dist 6 A 1-2-0) 0 |
| Chestnut Ridge (Dist 5 AA 3-0-0) 48 Johnstown (Dist 6 AAAA 0-3-0) 0 |
| Northern Bedford (Dist 5 A 3-0-0) 37 Mount Union (Dist 6 AA 2-1-0) 13 |
| Windber (Dist 5 AA 3-0-0) 64 Tussey Mountain (Dist 5 A 1-2-0) 8 |
District 8 & 9 – September 2, 2022
| Westinghouse (Dist 8 AA 3-0-0) 39 Steelton-Highspire (Dist 3 A 1-1-0) 18 |
| Central Clarion (Dist 9 AA 3-0-0) 29 Port Allegany (Dist 9 A 2-1-0) 24 |
| Clearfield (Dist 9 AAA 2-1-0) 7 Bald Eagle Area (Dist 6 AA 1-2-0) 3 |
| Coudersport (Dist 9 A 1-2-0) 38 Bradford (Dist 9 AAAA 0-3-0) 27 |
| Curwensville (Dist 9 A 2-1-0) 36 Juniata Valley (Dist 6 A 1-2-0) 15 |
| DuBois (Dist 9 AAAA 2-1-0) 27 Brockway (Dist 9 AA 2-1-0) 26 |
| Elk County Catholic (Dist 9 A 3-0-0) 15 Moniteau (Dist 9 AA 1-2-0) 6 |
| Keystone (Dist 9 A 3-0-0) 43 Union_AC Valley (Dist 9 A 1-2-0) 7 |
| Punxsutawney (Dist 9 AAA 2-1-0) 37 Kane (Dist 9 AA 0-3-0) 16 |
| Redbank Valley (Dist 9 A 3-0-0) 25 Karns City (Dist 9 AA 1-2-0) 15 |
| Saint Marys (Dist 9 AAA 3-0-0) 27 Ridgway (Dist 9 AA 0-3-0) 6 |
| Smethport (Dist 9 A 1-2-0) 22 Cameron County (Dist 9 A 0-3-0) 6 |
District 6 – September 3, 2022
| Bishop Guilfoyle (Dist 6 AA 2-1-0) 35 Westmont Hilltop (Dist 6 AA 1-2-0) 21 |
District 5 – September 3, 2022
| Conemaugh Township (Dist 5 A 3-0-0) 28 Conemaugh Valley (Dist 6 A 0-3-0) 12 |
District 9 – September 3, 2022
| Otto-Eldred (Dist 9 A 2-1-0) 54 Sheffield (Dist 9 A 0-2-0) 6. |