December 2/3 2022
| Bishop McDevitt (3) (Dist 3 AAAA 12-1-0) 35 Crestwood (Dist 2 AAAA 13-2-0) 0 |
| Steelton-Highspire (Dist 3 A 12-1-0) 28 Canton (Dist 4 A 12-2-0) 21 |
| Southern Columbia (Dist 4 AA 12-3-0) 42 Trinity (3) (Dist 3 AA 9-5-0) 7 |
| Aliquippa (Dist 7 AAAA 13-0-0) 31 Allentown Central Catholic (Dist 11 AAAA 9-6-0) 10 |
| Belle Vernon (Dist 7 AAAA 11-2-0) 21 Central (Martinsburg) (Dist 6 AAA 12-3-0) 17 |
| Pine-Richland (Dist 7 AAAAA 12-3-0) 34 Cocalico (Dist 3 AAAA 10-5-0) 12 |
| Union Area (Dist 7 A 12-3-0) 46 Port Allegany (Dist 9 A 12-2-0) 36 |
| Westinghouse (Dist 8 AA 14-0-0) 26 Steel Valley (Dist 7 AA 12-1-0) 7 |
| Imhotep Charter (Dist 12 AAAAA 10-2-0) 21 Upper Dublin (Dist 1 AAAAA 14-1-0) 14 |
| Harrisburg (Dist 3 AAAAAA 11-2-0) 27 State College (Dist 6 AAAAAA 13-1-0) 7 |
| SS Neumann-Goretti (Dist 12 AAA 11-3-0) 20 Wyomissing (Dist 3 AAA 13-1-0) 17 |
| St. Joseph’s Prep (Dist 12 AAAAAA 11-1-0) 48 Garnet Valley (Dist 1 AAAAAA 13-1-0) 7 |